Effect of the inhibition of CYP3A4 or CYP2D6 on the pharmacokinetics and pharmacodynamics of oxycodone.

Kummer, Oliver

Effect of the inhibition of CYP3A4 or CYP2D6 on the pharmacokinetics and pharmacodynamics of oxycodone. [electronic resource] - European journal of clinical pharmacology Jan 2011 - 63-71 p. digital

Publication Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

1432-1041

10.1007/s00228-010-0893-3 doi


Adult
Analgesics, Opioid--adverse effects
Cross-Over Studies
Cytochrome P-450 CYP2D6 Inhibitors
Cytochrome P-450 CYP3A
Cytochrome P-450 CYP3A Inhibitors
Double-Blind Method
Drug Interactions
Genotype
Humans
Ketoconazole--pharmacology
Miosis
Morphinans--metabolism
Oxycodone--adverse effects
Oxymorphone--metabolism
Pain Measurement
Paroxetine--pharmacology
Placebos
Young Adult