Mechanisms of olfactory toxicity of the herbicide 2,6-dichlorobenzonitrile: essential roles of CYP2A5 and target-tissue metabolic activation.

Xie, Fang

Mechanisms of olfactory toxicity of the herbicide 2,6-dichlorobenzonitrile: essential roles of CYP2A5 and target-tissue metabolic activation. [electronic resource] - Toxicology and applied pharmacology Nov 2010 - 101-6 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural

1096-0333

10.1016/j.taap.2010.09.003 doi


Animals
Aryl Hydrocarbon Hydroxylases--metabolism
Biotransformation--drug effects
Cytochrome P-450 CYP2A6
Cytochrome P450 Family 2
Enzyme Activation
Herbicides--pharmacokinetics
Male
Mice
Mice, Congenic
Mice, Knockout
Nitriles--pharmacokinetics
Olfactory Mucosa--drug effects