Activated microglia mediate axoglial disruption that contributes to axonal injury in multiple sclerosis.

Howell, Owain W

Activated microglia mediate axoglial disruption that contributes to axonal injury in multiple sclerosis. [electronic resource] - Journal of neuropathology and experimental neurology Oct 2010 - 1017-1033 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1554-6578

10.1097/NEN.0b013e3181f3a5b1 doi


Adult
Aged
Analysis of Variance
Animals
Anti-Bacterial Agents--pharmacology
Axons--pathology
Brain--metabolism
CD3 Complex--metabolism
Calcium-Binding Proteins
Caspase 1--metabolism
DNA-Binding Proteins--metabolism
Encephalomyelitis, Autoimmune, Experimental--chemically induced
Female
Gene Expression Regulation--drug effects
Glycoproteins
HLA-DR Antigens--metabolism
Humans
Indoles
Kv1.2 Potassium Channel--metabolism
Male
Mice
Mice, Inbred C57BL
Microfilament Proteins
Microglia--immunology
Microscopy, Confocal
Middle Aged
Minocycline--pharmacology
Multiple Sclerosis--pathology
Myelin-Oligodendrocyte Glycoprotein
NAV1.6 Voltage-Gated Sodium Channel
Nerve Tissue Proteins--metabolism
Neurofilament Proteins--metabolism
Nitric Oxide Synthase Type II--metabolism
Peptide Fragments
Postmortem Changes
Ranvier's Nodes--drug effects
Sodium Channels--metabolism
Toll-Like Receptor 4--metabolism