Overexpression of inosine 5'-monophosphate dehydrogenase type II mediates chemoresistance to human osteosarcoma cells.

Fellenberg, Jörg

Overexpression of inosine 5'-monophosphate dehydrogenase type II mediates chemoresistance to human osteosarcoma cells. [electronic resource] - PloS one Aug 2010 - e12179 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1932-6203

10.1371/journal.pone.0012179 doi


Animals
Apoptosis Regulatory Proteins--genetics
Cell Line, Tumor
Cell Proliferation--drug effects
Cisplatin--pharmacology
Drug Resistance, Neoplasm--genetics
Gene Expression Regulation, Neoplastic
Gene Knockdown Techniques
Humans
IMP Dehydrogenase--antagonists & inhibitors
Inhibitory Concentration 50
Methotrexate--pharmacology
Mycophenolic Acid--pharmacology
Osteosarcoma--genetics