Decreased folylpolyglutamate synthetase activity as a mechanism of methotrexate resistance in CCRF-CEM human leukemia sublines.

McCloskey, D E

Decreased folylpolyglutamate synthetase activity as a mechanism of methotrexate resistance in CCRF-CEM human leukemia sublines. [electronic resource] - The Journal of biological chemistry Apr 1991 - 6181-7 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

0021-9258


Drug Resistance
Humans
Leukemia--enzymology
Methotrexate--metabolism
Peptide Synthases--metabolism
Phenotype
Thymidylate Synthase--metabolism
Tumor Cells, Cultured