Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977.

Murakami, Eisuke

Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977. [electronic resource] - The Journal of biological chemistry Nov 2010 - 34337-47 p. digital

Publication Type: Journal Article

1083-351X

10.1074/jbc.M110.161802 doi


Antiviral Agents--pharmacokinetics
Carboxylic Ester Hydrolases--metabolism
Cathepsin A--metabolism
Cell Line
Hepacivirus--physiology
Hepatocytes--metabolism
Humans
Hydrolysis
Nucleoside-Phosphate Kinase--metabolism
Prodrugs--pharmacokinetics
RNA, Viral--metabolism
Sofosbuvir
Stereoisomerism
Uridine Monophosphate--analogs & derivatives
Viral Nonstructural Proteins--antagonists & inhibitors
Virus Replication--drug effects