Novel tetrahydroisoquinoline derivatives with inhibitory activities against acyl-CoA: cholesterol acyltransferase and lipid peroxidation.

Ohta, Masaru

Novel tetrahydroisoquinoline derivatives with inhibitory activities against acyl-CoA: cholesterol acyltransferase and lipid peroxidation. [electronic resource] - Chemical & pharmaceutical bulletin Aug 2010 - 1066-76 p. digital

Publication Type: Journal Article

1347-5223

10.1248/cpb.58.1066 doi


Animals
Antioxidants--chemical synthesis
Cell Death--drug effects
Cholesterol--metabolism
Dogs
Enzyme Inhibitors--chemical synthesis
Esterification
Lipid Peroxidation--drug effects
Macrophages--drug effects
Male
Molecular Structure
Oxidative Stress--drug effects
Rabbits
Rats
Rats, Sprague-Dawley
Stereoisomerism
Sterol O-Acyltransferase--antagonists & inhibitors
Structure-Activity Relationship
Tetrahydroisoquinolines--chemical synthesis