System-level analysis of neuroblastoma tumor-initiating cells implicates AURKB as a novel drug target for neuroblastoma.

Morozova, Olena

System-level analysis of neuroblastoma tumor-initiating cells implicates AURKB as a novel drug target for neuroblastoma. [electronic resource] - Clinical cancer research : an official journal of the American Association for Cancer Research Sep 2010 - 4572-82 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1557-3265

10.1158/1078-0432.CCR-10-0627 doi


Antineoplastic Agents--therapeutic use
Aurora Kinase B
Aurora Kinases
Chromatography, Liquid--methods
Drug Evaluation, Preclinical
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Gene Knockdown Techniques
Humans
Microarray Analysis
Molecular Targeted Therapy--methods
Neoplastic Stem Cells--metabolism
Neuroblastoma--drug therapy
Protein Kinase Inhibitors--therapeutic use
Protein Serine-Threonine Kinases--antagonists & inhibitors
RNA, Small Interfering--pharmacology
Systems Biology--methods
Tandem Mass Spectrometry--methods
Therapies, Investigational--methods
Validation Studies as Topic