trans-3-n-propyl-L-proline is a highly favorable, conformationally restricted replacement for methionine in the C-terminal tetrapeptide of cholecystokinin. Stereoselective synthesis of 3-allyl- and 3-n-propyl-L-proline derivatives from 4-hydroxy-L-proline.
Holladay, M W
trans-3-n-propyl-L-proline is a highly favorable, conformationally restricted replacement for methionine in the C-terminal tetrapeptide of cholecystokinin. Stereoselective synthesis of 3-allyl- and 3-n-propyl-L-proline derivatives from 4-hydroxy-L-proline. [electronic resource] - Journal of medicinal chemistry Jan 1991 - 455-7 p. digital
Publication Type: Comparative Study; Journal Article
0022-2623
10.1021/jm00105a068 doi
Animals
Cerebral Cortex--metabolism
Guinea Pigs
Hydroxyproline
Indicators and Reagents
Methionine
Molecular Structure
Pancreas--metabolism
Proline--analogs & derivatives
Receptors, Cholecystokinin--metabolism
Structure-Activity Relationship
Tetragastrin--analogs & derivatives
trans-3-n-propyl-L-proline is a highly favorable, conformationally restricted replacement for methionine in the C-terminal tetrapeptide of cholecystokinin. Stereoselective synthesis of 3-allyl- and 3-n-propyl-L-proline derivatives from 4-hydroxy-L-proline. [electronic resource] - Journal of medicinal chemistry Jan 1991 - 455-7 p. digital
Publication Type: Comparative Study; Journal Article
0022-2623
10.1021/jm00105a068 doi
Animals
Cerebral Cortex--metabolism
Guinea Pigs
Hydroxyproline
Indicators and Reagents
Methionine
Molecular Structure
Pancreas--metabolism
Proline--analogs & derivatives
Receptors, Cholecystokinin--metabolism
Structure-Activity Relationship
Tetragastrin--analogs & derivatives