Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening.

Rotroff, Daniel M

Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening. [electronic resource] - Toxicological sciences : an official journal of the Society of Toxicology Oct 2010 - 348-58 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

1096-0929

10.1093/toxsci/kfq220 doi


Cells, Cultured
Dose-Response Relationship, Drug
Female
Gas Chromatography-Mass Spectrometry
Hepatocytes--drug effects
High-Throughput Screening Assays--methods
Humans
Male
Metabolic Clearance Rate
Protein Binding--drug effects
Risk Assessment
Toxicity Tests
Xenobiotics--classification