Cytochrome P450 3A4 mRNA is a more reliable marker than CYP3A4 activity for detecting pregnane X receptor-activated induction of drug-metabolizing enzymes.
Fahmi, Odette A
Cytochrome P450 3A4 mRNA is a more reliable marker than CYP3A4 activity for detecting pregnane X receptor-activated induction of drug-metabolizing enzymes. [electronic resource] - Drug metabolism and disposition: the biological fate of chemicals Sep 2010 - 1605-11 p. digital
Publication Type: Journal Article
1521-009X
10.1124/dmd.110.033126 doi
Biocatalysis
Biomarkers--metabolism
Cells, Cultured
Cytochrome P-450 CYP3A--genetics
Hepatocytes--drug effects
Humans
Pregnane X Receptor
RNA, Messenger--genetics
Receptors, Steroid--physiology
Rifampin--metabolism
Steroid Hydroxylases--metabolism
Cytochrome P450 3A4 mRNA is a more reliable marker than CYP3A4 activity for detecting pregnane X receptor-activated induction of drug-metabolizing enzymes. [electronic resource] - Drug metabolism and disposition: the biological fate of chemicals Sep 2010 - 1605-11 p. digital
Publication Type: Journal Article
1521-009X
10.1124/dmd.110.033126 doi
Biocatalysis
Biomarkers--metabolism
Cells, Cultured
Cytochrome P-450 CYP3A--genetics
Hepatocytes--drug effects
Humans
Pregnane X Receptor
RNA, Messenger--genetics
Receptors, Steroid--physiology
Rifampin--metabolism
Steroid Hydroxylases--metabolism