Synthesis and biological evaluation of azobicyclo[3.3.0] octane derivatives as dipeptidyl peptidase 4 inhibitors for the treatment of type 2 diabetes.

Cho, Tang Peng

Synthesis and biological evaluation of azobicyclo[3.3.0] octane derivatives as dipeptidyl peptidase 4 inhibitors for the treatment of type 2 diabetes. [electronic resource] - Bioorganic & medicinal chemistry letters Jun 2010 - 3565-8 p. digital

Publication Type: Journal Article

1464-3405

10.1016/j.bmcl.2010.04.120 doi


Animals
Azo Compounds--chemical synthesis
Bridged Bicyclo Compounds--chemical synthesis
Diabetes Mellitus, Type 2--drug therapy
Dipeptidyl Peptidase 4--blood
Dipeptidyl-Peptidase IV Inhibitors--chemical synthesis
Glucose Tolerance Test
Hypoglycemic Agents--chemical synthesis
Mice
Mice, Inbred ICR
Octanes--chemical synthesis
Pharmacokinetics
Rats
Rats, Sprague-Dawley
Structure-Activity Relationship