Decreased transcription-coupled nucleotide excision repair capacity is associated with increased p53- and MLH1-independent apoptosis in response to cisplatin.

Stubbert, Lawton J

Decreased transcription-coupled nucleotide excision repair capacity is associated with increased p53- and MLH1-independent apoptosis in response to cisplatin. [electronic resource] - BMC cancer May 2010 - 207 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1471-2407

10.1186/1471-2407-10-207 doi


Adaptor Proteins, Signal Transducing--genetics
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Cisplatin--pharmacology
Colorectal Neoplasms--enzymology
DNA Helicases--genetics
DNA Repair--radiation effects
DNA Repair Enzymes--genetics
Dose-Response Relationship, Drug
Dose-Response Relationship, Radiation
Down-Regulation
Drug Resistance, Neoplasm
Gene Expression Regulation, Neoplastic
HCT116 Cells
Humans
Male
MutL Protein Homolog 1
Nuclear Proteins--genetics
Poly-ADP-Ribose Binding Proteins
Prostatic Neoplasms--enzymology
RNA Interference
Transcription, Genetic
Tumor Suppressor Protein p53--genetics
Ultraviolet Rays
Up-Regulation
Xeroderma Pigmentosum Group A Protein--genetics