Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner.

Kalender, Adem

Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner. [electronic resource] - Cell metabolism May 2010 - 390-401 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1932-7420

10.1016/j.cmet.2010.03.014 doi


AMP-Activated Protein Kinases--metabolism
Amino Acid Sequence
Animals
Cell Line
Drosophila--metabolism
Glucose--metabolism
Hypoglycemic Agents--pharmacology
Mechanistic Target of Rapamycin Complex 1
Metformin--pharmacology
Mice
Molecular Sequence Data
Monomeric GTP-Binding Proteins--metabolism
Multiprotein Complexes
Phenformin--pharmacology
Proteins
Sequence Alignment
Signal Transduction
TOR Serine-Threonine Kinases
Transcription Factors--antagonists & inhibitors
Tuberous Sclerosis Complex 1 Protein
Tuberous Sclerosis Complex 2 Protein
Tumor Suppressor Proteins--metabolism