Reduction of fibrosis-related arrhythmias by chronic renin-angiotensin-aldosterone system inhibitors in an aged mouse model.

Stein, Mera

Reduction of fibrosis-related arrhythmias by chronic renin-angiotensin-aldosterone system inhibitors in an aged mouse model. [electronic resource] - American journal of physiology. Heart and circulatory physiology Aug 2010 - H310-21 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1522-1539

10.1152/ajpheart.01137.2009 doi


Age Factors
Aging
Angiotensin II Type 1 Receptor Blockers--pharmacology
Animals
Arrhythmias, Cardiac--etiology
Blood Pressure--drug effects
Cardiac Pacing, Artificial
Cell Communication--drug effects
Cellular Senescence
Connexin 43--metabolism
Disease Models, Animal
Echocardiography, Doppler
Electrocardiography
Epicardial Mapping
Eplerenone
Female
Fibrosis
Heart Conduction System--drug effects
Heart Diseases--complications
Losartan--pharmacology
Mice
Mice, Inbred C57BL
Mineralocorticoid Receptor Antagonists--pharmacology
Myocardium--metabolism
Renin-Angiotensin System--drug effects
Spironolactone--analogs & derivatives
Ventricular Function, Left--drug effects
Ventricular Function, Right--drug effects