Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles.

Davis, Mark E

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles. [electronic resource] - Nature Apr 2010 - 1067-70 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1476-4687

10.1038/nature08956 doi


Biopsy
Clinical Trials, Phase I as Topic
Drug Carriers--administration & dosage
Drug Delivery Systems
Gene Knockdown Techniques--methods
Humans
Injections, Intravenous
Melanoma--drug therapy
Nanoparticles--administration & dosage
RNA Interference--drug effects
RNA, Messenger--analysis
RNA, Small Interfering--administration & dosage
Receptors, Transferrin--metabolism
Ribonucleoside Diphosphate Reductase--biosynthesis