AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity.

Chresta, Christine M

AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity. [electronic resource] - Cancer research Jan 2010 - 288-98 p. digital

Publication Type: Journal Article

1538-7445

10.1158/0008-5472.CAN-09-1751 doi


Animals
Antineoplastic Agents--pharmacology
Cell Proliferation--drug effects
Female
Humans
Mice
Mice, Nude
Morpholines--pharmacology
Neoplasms, Experimental--drug therapy
Protein Kinase Inhibitors--pharmacology
Protein Kinases--drug effects
Signal Transduction--drug effects
TOR Serine-Threonine Kinases
Xenograft Model Antitumor Assays