Application of a novel [3+2] cycloaddition reaction to prepare substituted imidazoles and their use in the design of potent DFG-out allosteric B-Raf inhibitors.
Dietrich, Justin
Application of a novel [3+2] cycloaddition reaction to prepare substituted imidazoles and their use in the design of potent DFG-out allosteric B-Raf inhibitors. [electronic resource] - Bioorganic & medicinal chemistry Jan 2010 - 292-304 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1464-3391
10.1016/j.bmc.2009.10.055 doi
Animals
Cyclization
Humans
Imidazoles--chemical synthesis
Mice
Models, Molecular
Protein Binding
Protein Kinase Inhibitors--chemistry
Proto-Oncogene Proteins B-raf--antagonists & inhibitors
Application of a novel [3+2] cycloaddition reaction to prepare substituted imidazoles and their use in the design of potent DFG-out allosteric B-Raf inhibitors. [electronic resource] - Bioorganic & medicinal chemistry Jan 2010 - 292-304 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1464-3391
10.1016/j.bmc.2009.10.055 doi
Animals
Cyclization
Humans
Imidazoles--chemical synthesis
Mice
Models, Molecular
Protein Binding
Protein Kinase Inhibitors--chemistry
Proto-Oncogene Proteins B-raf--antagonists & inhibitors