Glucocorticoids increase alpha5 integrin expression and adhesion of synovial fibroblasts but inhibit ERK signaling, migration, and cartilage invasion.

Lowin, Torsten

Glucocorticoids increase alpha5 integrin expression and adhesion of synovial fibroblasts but inhibit ERK signaling, migration, and cartilage invasion. [electronic resource] - Arthritis and rheumatism Dec 2009 - 3623-32 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0004-3591

10.1002/art.24985 doi


Aged
Animals
Antibodies, Neutralizing--pharmacology
Cartilage, Articular--drug effects
Cell Movement--drug effects
Cells, Cultured
Estradiol--pharmacology
Extracellular Signal-Regulated MAP Kinases--antagonists & inhibitors
Female
Fibroblasts--drug effects
Gene Expression
Humans
Hydrocortisone--pharmacology
Integrin alpha5--genetics
Male
Mice
Mice, SCID
RNA Interference
RNA, Small Interfering--genetics
Signal Transduction--drug effects
Synovial Membrane--drug effects
Testosterone--pharmacology