Taiwan cobra phospholipase A2-elicited JNK activation is responsible for autocrine fas-mediated cell death and modulating Bcl-2 and Bax protein expression in human leukemia K562 cells.

Chen, Ku-Chung

Taiwan cobra phospholipase A2-elicited JNK activation is responsible for autocrine fas-mediated cell death and modulating Bcl-2 and Bax protein expression in human leukemia K562 cells. [electronic resource] - Journal of cellular biochemistry Jan 2010 - 245-54 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1097-4644

10.1002/jcb.22404 doi


Apoptosis--physiology
Blotting, Western
Cell Separation
Cell Survival--drug effects
Elapid Venoms--enzymology
Enzyme Activation--physiology
Enzyme Inhibitors--pharmacology
Fas Ligand Protein--metabolism
Flow Cytometry
Humans
K562 Cells
Leukemia--metabolism
MAP Kinase Kinase 4--metabolism
Membrane Potential, Mitochondrial--drug effects
Phospholipases A2--metabolism
Proto-Oncogene Proteins c-bcl-2--biosynthesis
RNA Interference
Signal Transduction--drug effects
Transfection
bcl-2-Associated X Protein--biosynthesis
fas Receptor--metabolism