Overexpression of the wild-type SPT1 subunit lowers desoxysphingolipid levels and rescues the phenotype of HSAN1.

Eichler, Florian S

Overexpression of the wild-type SPT1 subunit lowers desoxysphingolipid levels and rescues the phenotype of HSAN1. [electronic resource] - The Journal of neuroscience : the official journal of the Society for Neuroscience Nov 2009 - 14646-51 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1529-2401

10.1523/JNEUROSCI.2536-09.2009 doi


Animals
Cricetinae
Gene Expression
Hereditary Sensory and Autonomic Neuropathies--genetics
Male
Mice
Mice, Inbred C3H
Mice, Knockout
Mice, Transgenic
Phenotype
Protein Subunits--biosynthesis
Serine C-Palmitoyltransferase--biosynthesis
Sphingolipids--metabolism