De novo discovery of a gamma-secretase inhibitor response signature using a novel in vivo breast tumor model.

Watters, James W

De novo discovery of a gamma-secretase inhibitor response signature using a novel in vivo breast tumor model. [electronic resource] - Cancer research Dec 2009 - 8949-57 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1538-7445

10.1158/0008-5472.CAN-09-1544 doi


Amyloid Precursor Protein Secretases--antagonists & inhibitors
Animals
Cell Growth Processes--drug effects
Cyclic S-Oxides--administration & dosage
Drug Administration Schedule
Enzyme Inhibitors--administration & dosage
Gene Regulatory Networks
Humans
Mammary Neoplasms, Experimental--drug therapy
Mice
Mice, Inbred C57BL
Mice, Transgenic
Thiadiazoles--administration & dosage