Regulation of heme synthesis and proteasomal activity by copper: possible implications for Wilson's disease.

Hait-Darshan, Ravit

Regulation of heme synthesis and proteasomal activity by copper: possible implications for Wilson's disease. [electronic resource] - Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 2009 - 209-21 p. digital

Publication Type: Journal Article

2162-6537

10.1615/jenvironpatholtoxicoloncol.v28.i3.20 doi


Adenosine Triphosphatases--biosynthesis
Carcinoma, Hepatocellular--drug therapy
Cation Transport Proteins--biosynthesis
Cell Line, Tumor
Cell Survival--drug effects
Copper--toxicity
Copper-Transporting ATPases
Disulfiram--pharmacology
Down-Regulation--drug effects
Enzyme Inhibitors--toxicity
Heme--biosynthesis
Hepatocytes--drug effects
Hepatolenticular Degeneration
Humans
Hydroxymethylbilane Synthase--antagonists & inhibitors
Liver Neoplasms--drug therapy
Porphobilinogen Synthase--antagonists & inhibitors
Proteasome Endopeptidase Complex--drug effects
Protoporphyrins--metabolism
Reactive Oxygen Species--metabolism
Ubiquitin--metabolism