Enhanced Fas-associated death domain recruitment by histone deacetylase inhibitors is critical for the sensitization of chronic lymphocytic leukemia cells to TRAIL-induced apoptosis.

Inoue, Satoshi

Enhanced Fas-associated death domain recruitment by histone deacetylase inhibitors is critical for the sensitization of chronic lymphocytic leukemia cells to TRAIL-induced apoptosis. [electronic resource] - Molecular cancer therapeutics Nov 2009 - 3088-97 p. digital

Publication Type: Journal Article

1538-8514

10.1158/1535-7163.MCT-09-0451 doi


Antineoplastic Combined Chemotherapy Protocols--pharmacology
Apoptosis--drug effects
Apoptosis Inducing Factor--metabolism
Blotting, Western
Depsipeptides--administration & dosage
Drug Synergism
Fas-Associated Death Domain Protein--metabolism
Histone Deacetylase Inhibitors--administration & dosage
Histone Deacetylases--metabolism
Humans
Intracellular Signaling Peptides and Proteins--metabolism
Leukemia, Lymphocytic, Chronic, B-Cell--drug therapy
Phosphorylation--drug effects
Protein Kinase C--metabolism
Protein Kinase C beta
Protein Tyrosine Phosphatase, Non-Receptor Type 6--metabolism
Protein-Tyrosine Kinases--metabolism
Receptors, TNF-Related Apoptosis-Inducing Ligand
Receptors, Tumor Necrosis Factor--metabolism
Signal Transduction--drug effects
Syk Kinase
TNF-Related Apoptosis-Inducing Ligand--administration & dosage
Tetradecanoylphorbol Acetate--pharmacology
Tumor Cells, Cultured
src-Family Kinases--metabolism