Study of the impact of the T877A mutation on ligand-induced helix-12 positioning of the androgen receptor resulted in design and synthesis of novel antiandrogens.
Zhou, Jinming
Study of the impact of the T877A mutation on ligand-induced helix-12 positioning of the androgen receptor resulted in design and synthesis of novel antiandrogens. [electronic resource] - Proteins Feb 2010 - 623-37 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1097-0134
10.1002/prot.22592 doi
Androgen Antagonists--chemical synthesis
Androgen Receptor Antagonists
Binding Sites
Cluster Analysis
Drug Design
Flutamide--analogs & derivatives
Ligands
Molecular Dynamics Simulation
Mutation
Principal Component Analysis
Protein Interaction Domains and Motifs
Receptors, Androgen--chemistry
Study of the impact of the T877A mutation on ligand-induced helix-12 positioning of the androgen receptor resulted in design and synthesis of novel antiandrogens. [electronic resource] - Proteins Feb 2010 - 623-37 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1097-0134
10.1002/prot.22592 doi
Androgen Antagonists--chemical synthesis
Androgen Receptor Antagonists
Binding Sites
Cluster Analysis
Drug Design
Flutamide--analogs & derivatives
Ligands
Molecular Dynamics Simulation
Mutation
Principal Component Analysis
Protein Interaction Domains and Motifs
Receptors, Androgen--chemistry