Glucuronidation and covalent protein binding of benoxaprofen and flunoxaprofen in sandwich-cultured rat and human hepatocytes.

Dong, Jennifer Q

Glucuronidation and covalent protein binding of benoxaprofen and flunoxaprofen in sandwich-cultured rat and human hepatocytes. [electronic resource] - Drug metabolism and disposition: the biological fate of chemicals Dec 2009 - 2314-22 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural

1521-009X

10.1124/dmd.109.028944 doi


Adult
Animals
Anti-Inflammatory Agents, Non-Steroidal--metabolism
Benzoxazoles--metabolism
Biotransformation
Cell Culture Techniques
Collagen
Dose-Response Relationship, Drug
Drug Combinations
Feasibility Studies
Glucuronates--metabolism
Glucuronosyltransferase--metabolism
Hepatocytes--metabolism
Humans
Ibuprofen--metabolism
Kinetics
Laminin
Male
Microsomes, Liver--metabolism
Models, Biological
Propionates--metabolism
Protein Binding
Proteoglycans
Rats
Rats, Sprague-Dawley