Generation of Epstein-Barr virus-specific cytotoxic T lymphocytes resistant to the immunosuppressive drug tacrolimus (FK506).

De Angelis, Biagio

Generation of Epstein-Barr virus-specific cytotoxic T lymphocytes resistant to the immunosuppressive drug tacrolimus (FK506). [electronic resource] - Blood Nov 2009 - 4784-91 p. digital

Publication Type: Journal Article

1528-0020

10.1182/blood-2009-07-230482 doi


Adoptive Transfer
Animals
Antigens, Viral--immunology
Cells, Cultured--drug effects
Cytotoxicity, Immunologic
Drug Resistance--genetics
Gene Knockdown Techniques
Genetic Vectors--pharmacology
Herpesvirus 4, Human--immunology
Humans
Immunosuppressive Agents--therapeutic use
Lymphoma, Non-Hodgkin--therapy
Mice
Mice, SCID
Protein Processing, Post-Translational
RNA, Messenger--antagonists & inhibitors
RNA, Small Interfering--physiology
Recombinant Fusion Proteins--antagonists & inhibitors
Retroviridae--genetics
Ribosomal Protein S6 Kinases--metabolism
T-Lymphocytes, Cytotoxic--drug effects
Tacrolimus--pharmacology
Tacrolimus Binding Protein 1A--antagonists & inhibitors
Xenograft Model Antitumor Assays