Modelling of patient EMS exposure: translating pharmacokinetics of EMS in vitro and in animals into patients.

Lavé, Thierry

Modelling of patient EMS exposure: translating pharmacokinetics of EMS in vitro and in animals into patients. [electronic resource] - Toxicology letters Nov 2009 - 310-6 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1879-3169

10.1016/j.toxlet.2009.07.031 doi


Alkylating Agents--pharmacokinetics
Animals
Area Under Curve
Computer Simulation
Dose-Response Relationship, Drug
Drug Contamination
Ethyl Methanesulfonate--pharmacokinetics
HIV Protease Inhibitors--chemistry
Hemoglobins--chemistry
Humans
In Vitro Techniques
Macaca fascicularis
Mice
Microsomes, Liver--drug effects
Models, Biological
Mutagens--pharmacokinetics
Nelfinavir--chemistry
Rats
Risk Assessment
Species Specificity
Valine--analogs & derivatives