Synthesis of a 1,4-benzodiazepine containing palladacycle with in vitro anticancer and cathepsin B activity.

Spencer, John

Synthesis of a 1,4-benzodiazepine containing palladacycle with in vitro anticancer and cathepsin B activity. [electronic resource] - Dalton transactions (Cambridge, England : 2003) Jun 2009 - 4299-303 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1477-9226

10.1039/b819061e doi


Animals
Antineoplastic Agents--chemical synthesis
Benzodiazepines--chemical synthesis
Cathepsin B--antagonists & inhibitors
Cell Line, Tumor
Cell Proliferation--drug effects
Cell Survival--drug effects
Chlorocebus aethiops
Crystallography, X-Ray
Drug Screening Assays, Antitumor
Humans
Inhibitory Concentration 50
Leukemia, Myelogenous, Chronic, BCR-ABL Positive--drug therapy
Liver--enzymology
Magnetic Resonance Spectroscopy
Models, Molecular
Molecular Structure
Palladium--chemistry
Vero Cells