The Ca2+ affinity of synaptotagmin 1 is markedly increased by a specific interaction of its C2B domain with phosphatidylinositol 4,5-bisphosphate.

Radhakrishnan, Anand

The Ca2+ affinity of synaptotagmin 1 is markedly increased by a specific interaction of its C2B domain with phosphatidylinositol 4,5-bisphosphate. [electronic resource] - The Journal of biological chemistry Sep 2009 - 25749-60 p. digital

Publication Type: Journal Article

1083-351X

10.1074/jbc.M109.042499 doi


Animals
Calcium--chemistry
Cell Membrane--chemistry
Liposomes--chemistry
Mutation
Neurotransmitter Agents--chemistry
Phosphatidylinositol 4,5-Diphosphate--chemistry
Protein Structure, Tertiary--physiology
Rats
Synaptotagmin I--chemistry