Octahydropyrrolo[3,4-c]pyrrole: a diamine scaffold for construction of either alpha4beta2 or alpha7-selective nicotinic acetylcholine receptor (nAChR) ligands. Substitutions that switch subtype selectivity.

Bunnelle, William H

Octahydropyrrolo[3,4-c]pyrrole: a diamine scaffold for construction of either alpha4beta2 or alpha7-selective nicotinic acetylcholine receptor (nAChR) ligands. Substitutions that switch subtype selectivity. [electronic resource] - Journal of medicinal chemistry Jul 2009 - 4126-41 p. digital

Publication Type: Journal Article

1520-4804

10.1021/jm900249k doi


Animals
Binding Sites
Cell Line
Diamines--chemistry
Humans
Ligands
Nicotinic Agonists--chemistry
Pyrroles--chemistry
Rats
Receptors, Nicotinic--metabolism
Structure-Activity Relationship
Substrate Specificity
alpha7 Nicotinic Acetylcholine Receptor