PKC-theta modulates the strength of T cell responses by targeting Cbl-b for ubiquitination and degradation.

Gruber, Thomas

PKC-theta modulates the strength of T cell responses by targeting Cbl-b for ubiquitination and degradation. [electronic resource] - Science signaling Jun 2009 - ra30 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1937-9145

10.1126/scisignal.2000046 doi


Adaptor Proteins, Signal Transducing--genetics
Animals
CD28 Antigens--genetics
Isoenzymes--genetics
Lymphocyte Activation--genetics
Mice
Mice, Knockout
Protein Kinase C--genetics
Protein Kinase C-theta
Proto-Oncogene Proteins c-cbl--genetics
Receptors, Antigen, T-Cell--genetics
T-Lymphocytes--enzymology
Ubiquitin-Protein Ligases--genetics
Ubiquitination--genetics