Blood-brain barrier transport of naloxone does not involve P-glycoprotein-mediated efflux.

Suzuki, Toyofumi

Blood-brain barrier transport of naloxone does not involve P-glycoprotein-mediated efflux. [electronic resource] - Journal of pharmaceutical sciences Jan 2010 - 413-21 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1520-6017

10.1002/jps.21819 doi


ATP Binding Cassette Transporter, Subfamily B
ATP Binding Cassette Transporter, Subfamily B, Member 1--antagonists & inhibitors
Animals
Biological Transport
Blood-Brain Barrier--metabolism
Brain--metabolism
Dose-Response Relationship, Drug
Half-Life
HeLa Cells
Humans
In Vitro Techniques
Male
Microinjections
Models, Biological
Naloxone--administration & dosage
Narcotic Antagonists--administration & dosage
Rats
Rats, Wistar
Tissue Distribution