A dyad of lymphoblastic lysosomal cysteine proteases degrades the antileukemic drug L-asparaginase.

Patel, Naina

A dyad of lymphoblastic lysosomal cysteine proteases degrades the antileukemic drug L-asparaginase. [electronic resource] - The Journal of clinical investigation Jul 2009 - 1964-73 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1558-8238

10.1172/JCI37977 doi


Antineoplastic Agents--metabolism
Asparaginase--metabolism
Cathepsin B--physiology
Cell Line
Cysteine Endopeptidases--physiology
Humans
Lymphocytes--enzymology
Lysosomes--enzymology
Precursor Cell Lymphoblastic Leukemia-Lymphoma--drug therapy