Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4-formation.

Schühly, Wolfgang

Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4-formation. [electronic resource] - Bioorganic & medicinal chemistry Jul 2009 - 4459-65 p. digital

Publication Type: Journal Article

1464-3391

10.1016/j.bmc.2009.05.018 doi


Arachidonate 5-Lipoxygenase--metabolism
Biphenyl Compounds--chemistry
Cyclooxygenase 1--metabolism
Cyclooxygenase 2--metabolism
Cyclooxygenase Inhibitors--chemical synthesis
Humans
Leukocytes--metabolism
Leukotriene B4--antagonists & inhibitors
Lignans--chemical synthesis
Magnolia--chemistry
Prostaglandin-Endoperoxide Synthases--metabolism
Structure-Activity Relationship