Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging.

Dai, Dao-Fu

Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging. [electronic resource] - Circulation Jun 2009 - 2789-97 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1524-4539

10.1161/CIRCULATIONAHA.108.822403 doi


Aging--metabolism
Animals
Calcium Signaling
Catalase--biosynthesis
DNA, Mitochondrial--analysis
Diastole
Fibrosis
Mice
Mice, Inbred C57BL
Mice, Transgenic
Mitochondria, Heart--chemistry
Models, Cardiovascular
Mutation
Myocytes, Cardiac--ultrastructure
NFATC Transcription Factors--analysis
Organ Specificity
Oxidative Stress
Reactive Oxygen Species
Recombinant Fusion Proteins--biosynthesis
Sarcoplasmic Reticulum Calcium-Transporting ATPases--analysis
Ultrasonography
Ventricular Dysfunction, Left--diagnostic imaging