Potent, brain-penetrant, hydroisoindoline-based human neurokinin-1 receptor antagonists.

Jiang, Jinlong

Potent, brain-penetrant, hydroisoindoline-based human neurokinin-1 receptor antagonists. [electronic resource] - Journal of medicinal chemistry May 2009 - 3039-46 p. digital

Publication Type: Journal Article

1520-4804

10.1021/jm8016514 doi


Administration, Oral
Animals
Aprepitant
Brain--metabolism
CHO Cells
Cricetinae
Cricetulus
Drug Interactions
Enzyme Inhibitors--chemical synthesis
Humans
Inhibitory Concentration 50
Isoindoles--chemical synthesis
Macaca mulatta
Morpholines--pharmacology
Neurokinin-1 Receptor Antagonists
Stereoisomerism