Resveratrol attenuates C5a-induced inflammatory responses in vitro and in vivo by inhibiting phospholipase D and sphingosine kinase activities.

Issuree, Priya D A

Resveratrol attenuates C5a-induced inflammatory responses in vitro and in vivo by inhibiting phospholipase D and sphingosine kinase activities. [electronic resource] - FASEB journal : official publication of the Federation of American Societies for Experimental Biology Aug 2009 - 2412-24 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1530-6860

10.1096/fj.09-130542 doi


Animals
Anti-Inflammatory Agents, Non-Steroidal--pharmacology
Biological Transport, Active--drug effects
Cell Degranulation--drug effects
Cell Membrane--drug effects
Chemokines--metabolism
Chemotaxis, Leukocyte--drug effects
Complement C5a--administration & dosage
Cytokines--metabolism
Disease Models, Animal
Enzyme Inhibitors--pharmacology
Extracellular Signal-Regulated MAP Kinases--metabolism
Humans
In Vitro Techniques
Inflammation--enzymology
Male
Mice
Mice, Inbred BALB C
NF-kappa B--metabolism
Neutrophils--drug effects
Peritonitis--etiology
Phospholipase D--antagonists & inhibitors
Phosphotransferases (Alcohol Group Acceptor)--antagonists & inhibitors
Respiratory Burst--drug effects
Resveratrol
Stilbenes--administration & dosage