A small-molecule modulator interacts directly with deltaPhe508-CFTR to modify its ATPase activity and conformational stability.

Wellhauser, Leigh

A small-molecule modulator interacts directly with deltaPhe508-CFTR to modify its ATPase activity and conformational stability. [electronic resource] - Molecular pharmacology Jun 2009 - 1430-8 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1521-0111

10.1124/mol.109.055608 doi


Adenosine Triphosphatases--metabolism
Animals
Cell Line
Cresols--pharmacology
Cricetinae
Cystic Fibrosis Transmembrane Conductance Regulator--genetics
Humans
Mutation
Protein Binding
Protein Conformation
Pyrazoles--pharmacology
Structure-Activity Relationship