Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component.

O'Keefe, Barry R

Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component. [electronic resource] - Proceedings of the National Academy of Sciences of the United States of America Apr 2009 - 6099-104 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural

1091-6490

10.1073/pnas.0901506106 doi


Algal Proteins--genetics
Animals
Cell Proliferation--drug effects
Cells, Cultured
Cervix Uteri--surgery
Cytokines--biosynthesis
Drug Evaluation, Preclinical
Female
HIV Envelope Protein gp120--metabolism
HIV Fusion Inhibitors--adverse effects
HIV Infections--prevention & control
HIV-1--drug effects
Humans
Lectins--genetics
Plant Lectins
Protein Binding
Rabbits
Tissue Culture Techniques
Tissue Transplantation
Nicotiana--genetics