1-Sulfonyl-4-acylpiperazines as selective cannabinoid-1 receptor (CB1R) inverse agonists for the treatment of obesity.

Vachal, Petr

1-Sulfonyl-4-acylpiperazines as selective cannabinoid-1 receptor (CB1R) inverse agonists for the treatment of obesity. [electronic resource] - Journal of medicinal chemistry Apr 2009 - 2550-8 p. digital

Publication Type: Journal Article

1520-4804

10.1021/jm900063x doi


Animals
Anti-Obesity Agents--chemical synthesis
Biological Availability
Body Weight--drug effects
Dogs
Drug Inverse Agonism
Eating--drug effects
Hepatocytes--metabolism
Humans
In Vitro Techniques
Macaca mulatta
Microsomes, Liver--metabolism
Models, Molecular
Piperazines--chemical synthesis
Rats
Receptor, Cannabinoid, CB1--antagonists & inhibitors
Stereoisomerism
Structure-Activity Relationship
Sulfonamides--chemical synthesis