Prediction of human pharmacokinetics from preclinical information: comparative accuracy of quantitative prediction approaches.

Hosea, Natilie A

Prediction of human pharmacokinetics from preclinical information: comparative accuracy of quantitative prediction approaches. [electronic resource] - Journal of clinical pharmacology May 2009 - 513-33 p. digital

Publication Type: Comparative Study; Journal Article

0091-2700

10.1177/0091270009333209 doi


Administration, Oral
Animals
Area Under Curve
Biological Availability
Biometry
Drug Evaluation, Preclinical--methods
Half-Life
Hepatocytes--metabolism
Humans
Metabolic Clearance Rate
Microsomes, Liver--metabolism
Models, Biological
Pharmacokinetics
Reproducibility of Results
Retrospective Studies
Species Specificity
Xenobiotics--pharmacokinetics