A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants.

Rodríguez, Antonio

A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants. [electronic resource] - Molecular cell Mar 2009 - 616-26 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1097-4164

10.1016/j.molcel.2009.01.030 doi


Amino Acid Motifs
Amino Acid Sequence
Animals
Binding Sites
Calcineurin--chemistry
Calcineurin Inhibitors
Cloning, Molecular
Computer Simulation
Conserved Sequence
Genes, Reporter
Humans
Hydrophobic and Hydrophilic Interactions
Immunophilins--metabolism
Immunosuppressive Agents--metabolism
Intracellular Signaling Peptides and Proteins
Jurkat Cells
Mice
Models, Molecular
Molecular Sequence Data
Mutagenesis, Site-Directed
Mutation
NFATC Transcription Factors--metabolism
Peptides--metabolism
Protein Conformation
Recombinant Fusion Proteins--metabolism
Saccharomyces cerevisiae Proteins--metabolism
Signal Transduction
Surface Properties
Tacrolimus Binding Protein 1A--metabolism
Transcription, Genetic
Transfection