Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery.
Lester, Henry A
Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery. [electronic resource] - The AAPS journal Mar 2009 - 167-77 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
1550-7416
10.1208/s12248-009-9090-7 doi
Acetylcholine--metabolism
Animals
Drug Discovery
Endoplasmic Reticulum--drug effects
Epilepsy, Frontal Lobe--genetics
Hippocampus--drug effects
Mice
Models, Biological
Muscle Proteins--biosynthesis
Mutation, Missense
Nerve Tissue Proteins--biosynthesis
Neurotransmitter Agents--physiology
Nicotine--pharmacokinetics
Parkinson Disease--prevention & control
Receptors, Nicotinic--biosynthesis
Smoking--metabolism
Tobacco Use Disorder--genetics
Up-Regulation--drug effects
Ventral Tegmental Area--drug effects
Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery. [electronic resource] - The AAPS journal Mar 2009 - 167-77 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
1550-7416
10.1208/s12248-009-9090-7 doi
Acetylcholine--metabolism
Animals
Drug Discovery
Endoplasmic Reticulum--drug effects
Epilepsy, Frontal Lobe--genetics
Hippocampus--drug effects
Mice
Models, Biological
Muscle Proteins--biosynthesis
Mutation, Missense
Nerve Tissue Proteins--biosynthesis
Neurotransmitter Agents--physiology
Nicotine--pharmacokinetics
Parkinson Disease--prevention & control
Receptors, Nicotinic--biosynthesis
Smoking--metabolism
Tobacco Use Disorder--genetics
Up-Regulation--drug effects
Ventral Tegmental Area--drug effects