The topoisomerase I poison CPT-11 enhances the effect of the aurora B kinase inhibitor AZD1152 both in vitro and in vivo.

Nair, Jayasree S

The topoisomerase I poison CPT-11 enhances the effect of the aurora B kinase inhibitor AZD1152 both in vitro and in vivo. [electronic resource] - Clinical cancer research : an official journal of the American Association for Cancer Research Mar 2009 - 2022-30 p. digital

Publication Type: Journal Article

1078-0432

10.1158/1078-0432.CCR-08-1826 doi


Animals
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Aurora Kinase B
Aurora Kinases
Camptothecin--analogs & derivatives
Cell Line, Tumor
Cell Proliferation--drug effects
Drug Synergism
Enzyme Inhibitors--pharmacology
Humans
Irinotecan
Mice
Organophosphates--pharmacology
Polyploidy
Protein Serine-Threonine Kinases--antagonists & inhibitors
Quinazolines--pharmacology
Topoisomerase I Inhibitors
Xenograft Model Antitumor Assays