Mutations of P450c21 (steroid 21-hydroxylase) at Cys428, Val281, and Ser268 result in complete, partial, or no loss of enzymatic activity, respectively.

Wu, D A

Mutations of P450c21 (steroid 21-hydroxylase) at Cys428, Val281, and Ser268 result in complete, partial, or no loss of enzymatic activity, respectively. [electronic resource] - The Journal of clinical investigation Aug 1991 - 519-23 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0021-9738

10.1172/JCI115334 doi


Adrenal Hyperplasia, Congenital--enzymology
Amino Acid Sequence
Animals
Base Sequence
Cell Line
Heme--metabolism
Humans
Kinetics
Molecular Sequence Data
Mutagenesis, Site-Directed
Mutation
Oligonucleotides
Sequence Alignment
Steroid 21-Hydroxylase--chemistry
Structure-Activity Relationship
Transfection