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Shi, Xianping

Triptolide inhibits Bcr-Abl transcription and induces apoptosis in STI571-resistant chronic myelogenous leukemia cells harboring T315I mutation. [electronic resource] - Clinical cancer research : an official journal of the American Association for Cancer Research Mar 2009 - 1686-97 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

ISSN: 1078-0432

Standard No.: 10.1158/1078-0432.CCR-08-2141 doi

Subjects--Topical Terms:
Adolescent
Adult
Aged
Animals
Antineoplastic Agents, Alkylating--therapeutic use
Apoptosis--drug effects
Benzamides
Blotting, Western
Cell Cycle--drug effects
Cell Proliferation--drug effects
Diterpenes--therapeutic use
Drug Resistance, Neoplasm
Epoxy Compounds--therapeutic use
Female
Flow Cytometry
Fusion Proteins, bcr-abl--antagonists & inhibitors
Humans
Imatinib Mesylate
Immunoenzyme Techniques
Leukemia, Myelogenous, Chronic, BCR-ABL Positive--drug therapy
Male
Membrane Potential, Mitochondrial--drug effects
Mice
Mice, Inbred BALB C
Mice, Nude
Middle Aged
Mutation--genetics
Myeloid Cell Leukemia Sequence 1 Protein
Phenanthrenes--therapeutic use
Piperazines--therapeutic use
Protein Kinase Inhibitors--therapeutic use
Protein-Tyrosine Kinases--antagonists & inhibitors
Proto-Oncogene Proteins c-akt--genetics
Proto-Oncogene Proteins c-bcl-2--genetics
Pyrimidines--therapeutic use
RNA, Messenger--genetics
Reactive Oxygen Species--metabolism
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction--drug effects
Transcription, Genetic--drug effects
Tripterygium--chemistry
Tumor Cells, Cultured
Tumor Stem Cell Assay
Xenograft Model Antitumor Assays
Young Adult