KR-31761, a novel K+(ATP)-channel opener, exerts cardioprotective effects by opening both mitochondrial K+(ATP) and Sarcolemmal K+(ATP) channels in rat models of ischemia/reperfusion-induced heart injury.

Yang, Min-Kyu

KR-31761, a novel K+(ATP)-channel opener, exerts cardioprotective effects by opening both mitochondrial K+(ATP) and Sarcolemmal K+(ATP) channels in rat models of ischemia/reperfusion-induced heart injury. [electronic resource] - Journal of pharmacological sciences Feb 2009 - 222-32 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1347-8613

10.1254/jphs.08132fp doi


Animals
Benzopyrans--therapeutic use
Cardiotonic Agents--therapeutic use
Disease Models, Animal
In Vitro Techniques
Indoles--therapeutic use
KATP Channels--agonists
Male
Mitochondria, Heart--drug effects
Potassium Channels--agonists
Rats
Rats, Sprague-Dawley
Reperfusion Injury--drug therapy
Sarcolemma--drug effects
Vasodilation--drug effects