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The hypoxia-activated ProDrug AQ4N penetrates deeply in tumor tissues and complements the limited distribution of mitoxantrone.

Trédan, Olivier

The hypoxia-activated ProDrug AQ4N penetrates deeply in tumor tissues and complements the limited distribution of mitoxantrone. [electronic resource] - Cancer research Feb 2009 - 940-7 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

ISSN: 1538-7445

Standard No.: 10.1158/0008-5472.CAN-08-0676 doi

Subjects--Topical Terms:
Animals
Anthraquinones--administration & dosage
Antineoplastic Combined Chemotherapy Protocols--pharmacokinetics
Cell Hypoxia
Humans
Male
Mice
Mitoxantrone--administration & dosage
Neoplasms--drug therapy
Prodrugs--administration & dosage
Xenograft Model Antitumor Assays

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