Inhibition of class I phosphoinositide 3-kinase activity impairs proliferation and triggers apoptosis in acute promyelocytic leukemia without affecting atra-induced differentiation.

Billottet, Clotilde

Inhibition of class I phosphoinositide 3-kinase activity impairs proliferation and triggers apoptosis in acute promyelocytic leukemia without affecting atra-induced differentiation. [electronic resource] - Cancer research Feb 2009 - 1027-36 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1538-7445

10.1158/0008-5472.CAN-08-2608 doi


Antineoplastic Combined Chemotherapy Protocols--pharmacology
Apoptosis--drug effects
Cell Differentiation--drug effects
Cell Growth Processes
Humans
Isoenzymes
Leukemia, Promyelocytic, Acute--drug therapy
Myeloid Cell Leukemia Sequence 1 Protein
Phosphatidylinositol 3-Kinases--metabolism
Phosphoinositide-3 Kinase Inhibitors
Protein Kinase Inhibitors--administration & dosage
Protein Kinases--metabolism
Proto-Oncogene Proteins c-akt--metabolism
Proto-Oncogene Proteins c-bcl-2--metabolism
Signal Transduction--drug effects
Sirolimus--pharmacology
Substrate Specificity
TOR Serine-Threonine Kinases
Tretinoin--administration & dosage
Up-Regulation--drug effects